The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage

In response to ER stress, the pancreatic endoplasmic reticulum kinase (PERK) coordinates an adaptive program known as the integrated stress response (ISR) by phosphorylating the α subunit of eukaryotic translation initiation factor 2 (eIF2α). IFN-γ, which activates the ER stress response in oligoden...

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Bibliografiset tiedot
Päätekijät: Lin, Wensheng, Bailey, Samantha L., Ho, Hanson, Harding, Heather P., Ron, David, Miller, Stephen D., Popko, Brian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2007
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783809/
https://ncbi.nlm.nih.gov/pubmed/17273557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29571
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