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The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage
In response to ER stress, the pancreatic endoplasmic reticulum kinase (PERK) coordinates an adaptive program known as the integrated stress response (ISR) by phosphorylating the α subunit of eukaryotic translation initiation factor 2 (eIF2α). IFN-γ, which activates the ER stress response in oligoden...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1783809/ https://ncbi.nlm.nih.gov/pubmed/17273557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29571 |
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