Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids

An important component of triple-drug anti-AIDS therapy is 2′,3′-dideoxy-3′-thiacytidine (3TC, lamivudine). Single mutations at residue 184 of the reverse transcriptase (RT) in HIV cause high-level resistance to 3TC and contribute to the failure of anti-AIDS combination therapy. We have determined c...

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Main Authors: Sarafianos, Stefan G., Das, Kalyan, Clark, Arthur D., Ding, Jianping, Boyer, Paul L., Hughes, Stephen H., Arnold, Edward
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC17836/
https://ncbi.nlm.nih.gov/pubmed/10468556
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