DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8(+) T cells in a spectrum of human MHC I haplotypes

Optimal HIV vaccines should elicit CD8(+) T cells specific for HIV proteins presented on MHC class I products, because these T cells contribute to host resistance to viruses. We had previously found that the targeting of antigen to dendritic cells (DCs) in mice efficiently induces CD8(+) T cell resp...

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Bibliographic Details
Main Authors: Bozzacco, Leonia, Trumpfheller, Christine, Siegal, Frederick P., Mehandru, Saurabh, Markowitz, Martin, Carrington, Mary, Nussenzweig, Michel C., Piperno, Angela Granelli, Steinman, Ralph M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783096/
https://ncbi.nlm.nih.gov/pubmed/17229838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610383104
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