Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation

Oligodeoxynucleotides (ODN) with unmethylated CpG dinucleotides mimic the immune stimulatory activity of bacterial DNA in vertebrates and are recognized by Toll-like receptor 9 (TLR9). It is also possible to detect immune activation with certain phosphorothioate sequences that lack CpG motifs. These...

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Autors principals: Vollmer, Jörg, Weeratna, Risini D, Jurk, Marion, Samulowitz, Ulrike, Mccluskie, Michael J, Payette, Paul, Davis, Heather L, Schetter, Christian, Krieg, Arthur M
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2004
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782571/
https://ncbi.nlm.nih.gov/pubmed/15379982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2004.01962.x
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