CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity

Synthetic oligodeoxynucleotides (ODN) that contain unmethylated CpG motifs (CpG ODN) induce macrophages to secrete IL-12, which induces interferon (IFN)-γ secretion by natural killer (NK) cells. Since these cytokines can induce T helper 1 (Th1) differentiation, we examined the effects of coadministe...

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Main Authors: Chu, Rose S., Targoni, Oleg S., Krieg, Arthur M., Lehmann, Paul V., Harding, Clifford V.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 1997
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199137/
https://ncbi.nlm.nih.gov/pubmed/9362523
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