Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced arthritis and establishes lasting disease resistance

Agonistic antibodies against CD137 act as costimulators in the activation of CD8 T cells. They enhance the immune response against syngeneic tumour grafts and suppress T cell-dependent humoral immune responses in vivo. The present study was undertaken to determine whether suppression of antibody pro...

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Detalhes bibliográficos
Main Authors: Foell, Juergen L, Diez-Mendiondo, Belkis I, Diez, Oliver H, Holzer, Ursula, Ruck, Peter, Bapat, Abhijit S, Hoffmann, Michael K, Mittler, Robert S, Dannecker, Guenther E
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782553/
https://ncbi.nlm.nih.gov/pubmed/15312139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2004.01952.x
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