CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F(1) mice

Systemic lupus erythematosus (SLE) is a CD4(+) T cell–dependent, immune complex–mediated, autoimmune disease that primarily affects women of childbearing age. Generation of high-titer affinity-matured IgG autoantibodies, specific for double-stranded DNA and other nuclear antigens, coincides with dis...

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Detalhes bibliográficos
Main Authors: Foell, Juergen, Strahotin, Simona, O’Neil, Shawn P., McCausland, Megan M., Suwyn, Carolyn, Haber, Michael, Chander, Praveen N., Bapat, Abhijit S., Yan, Xiao-Jie, Chiorazzi, Nicholas, Hoffmann, Michael K., Mittler, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155050/
https://ncbi.nlm.nih.gov/pubmed/12750400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317662
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