Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-κB pathway

Upon DNA damage, a complex called the PIDDosome is formed and either signals NF-κB activation and thus cell survival or alternatively triggers caspase-2 activation and apoptosis. PIDD (p53-induced protein with a death domain) is constitutively processed giving rise to a 48-kDa N-terminal fragment co...

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Autores principales: Tinel, Antoine, Janssens, Sophie, Lippens, Saskia, Cuenin, Solange, Logette, Emmanuelle, Jaccard, Bastienne, Quadroni, Manfredo, Tschopp, Jürg
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782377/
https://ncbi.nlm.nih.gov/pubmed/17159900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601473
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