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Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-κB pathway
Upon DNA damage, a complex called the PIDDosome is formed and either signals NF-κB activation and thus cell survival or alternatively triggers caspase-2 activation and apoptosis. PIDD (p53-induced protein with a death domain) is constitutively processed giving rise to a 48-kDa N-terminal fragment co...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1782377/ https://ncbi.nlm.nih.gov/pubmed/17159900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601473 |
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