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HLA-DQ8 as an Ir gene in coeliac disease

DQ8 restricted gliadin peptide is immunogenic in the intestinal mucosa of HLA-DQ8 positive patients, representing the first demonstration that a given peptide may be of pathogenic significance only for a subset of coeliacs, and strongly suggests that DQ2 and DQ8 act as immune response (Ir) genes in...

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Autore principale: Lundin, K E A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Copyright 2003 by Gut 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773536/
https://ncbi.nlm.nih.gov/pubmed/12477747
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