An immunodominant DQ8 restricted gliadin peptide activates small intestinal immune response in in vitro cultured mucosa from HLA-DQ8 positive but not HLA-DQ8 negative coeliac patients

Background: Studies on intestinal T cell clones from the mucosa of patients with coeliac disease have led to the identification of immunogenic gliadin epitopes. One is HLA-DQ8 restricted, its recognition by T cells being increased by introduction of negatively charged residues operated by tissue tra...

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Autors principals: Mazzarella, G, Maglio, M, Paparo, F, Nardone, G, Stefanile, R, Greco, L, van de Wal, Y, Kooy, Y, Koning, F, Auricchio, S, Troncone, R
Format: Artigo
Idioma:Inglês
Publicat: Copyright 2003 by Gut 2003
Matèries:
Small Intestine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773526/
https://ncbi.nlm.nih.gov/pubmed/12477760
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