Gliadin Activates HLA Class I-Restricted CD8(+) T Cells in Celiac Disease Intestinal Mucosa and Induces the Enterocyte Apoptosis

BACKGROUND & AIMS: The extensive infiltration of CD8(+) T cells in the intestinal mucosa of celiac disease (CD) patients is a hallmark of the disease. We identified a gliadin peptide (pA2) that is selectively recognized by CD8(+) T cells infiltrating intestinal mucosa of HLA-A2(+) CD patients. H...

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Main Authors: MAZZARELLA, GIUSEPPE, STEFANILE, ROSITA, CAMARCA, ALESSANDRA, GILIBERTI, PAOLO, COSENTINI, ELENA, MARANO, CATERINA, IAQUINTO, GAETANO, GIARDULLO, NICOLA, AURICCHIO, SALVATORE, SETTE, ALESSANDRO, TRONCONE, RICCARDO, GIANFRANI, CARMEN
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319059/
https://ncbi.nlm.nih.gov/pubmed/18395083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.01.008
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