Hypomorphic Mutation in PGC1β causes mitochondrial dysfunction and liver insulin resistance

PGC1β is a transcriptional coactivator that potently stimulates mitochondrial biogenesis and respiration of cells. Here, we have generated mice lacking exons 3 to 4 of the Pgc1β gene (PGC1β (E3,4-/E3,4-) mice). These mice express a mutant protein that has reduced coactivation activity on a subset of...

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Main Authors: Vianna, Claudia R., Huntgeburth, Michael, Coppari, Roberto, Choi, Cheol Soo, Lin, Jiandie, Krauss, Stefan, Barbatelli, Giorgio, Tzameli, Iphigenia, Kim, Young-Bum, Cinti, Saverio, Shulman, Gerald I., Spiegelman, Bruce M., Lowell, Bradford B.
Format: Artigo
Language:Inglês
Published: 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1764615/
https://ncbi.nlm.nih.gov/pubmed/17141629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2006.11.00
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