Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

Peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α has been shown to play critical roles in regulating mitochondria biogenesis, respiration, and muscle oxidative phenotype. Furthermore, reductions in the expression of PGC-1α in muscle have been implicated in the pathogenesis of type 2...

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Detalhes bibliográficos
Main Authors: Choi, Cheol Soo, Befroy, Douglas E., Codella, Roberto, Kim, Sheene, Reznick, Richard M., Hwang, Yu-Jin, Liu, Zhen-Xiang, Lee, Hui-Young, Distefano, Alberto, Samuel, Varman T., Zhang, Dongyan, Cline, Gary W., Handschin, Christoph, Lin, Jiandie, Petersen, Kitt F., Spiegelman, Bruce M., Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2598730/
https://ncbi.nlm.nih.gov/pubmed/19066218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810339105
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