Continuous fat oxidation in acetyl–CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

Acetyl–CoA carboxylase 2 (ACC)2 is a key regulator of mitochondrial fat oxidation. To examine the impact of ACC2 deletion on whole-body energy metabolism, we measured changes in substrate oxidation and total energy expenditure in Acc2(−/−) and WT control mice fed either regular or high-fat diets. To...

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Detalhes bibliográficos
Main Authors: Choi, Cheol Soo, Savage, David B., Abu-Elheiga, Lutfi, Liu, Zhen-Xiang, Kim, Sheene, Kulkarni, Ameya, Distefano, Alberto, Hwang, Yu-Jin, Reznick, Richard M., Codella, Roberto, Zhang, Dongyan, Cline, Gary W., Wakil, Salih J., Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034222/
https://ncbi.nlm.nih.gov/pubmed/17923673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706794104
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