Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk

The transcriptional coactivator PPARγ coactivator 1α (PGC-1α) is a strong activator of mitochondrial biogenesis and oxidative metabolism. While expression of PGC-1α and many of its mitochondrial target genes are decreased in the skeletal muscle of patients with type 2 diabetes, no causal relationshi...

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Bibliographic Details
Main Authors: Handschin, Christoph, Choi, Cheol Soo, Chin, Sherry, Kim, Sheene, Kawamori, Dan, Kurpad, Amarnath J., Neubauer, Nicole, Hu, Jiang, Mootha, Vamsi K., Kim, Young-Bum, Kulkarni, Rohit N., Shulman, Gerald I., Spiegelman, Bruce M.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000810/
https://ncbi.nlm.nih.gov/pubmed/17932564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31785
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