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Development of insulin resistance in mice lacking PGC-1α in adipose tissues

Reduced peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) expression and mitochondrial dysfunction in adipose tissue have been associated with obesity and insulin resistance. Whether this association is causally involved in the development of insulin resistance or is only a conseq...

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Hlavní autoři: Kleiner, Sandra, Mepani, Rina J., Laznik, Dina, Ye, Li, Jurczak, Michael J., Jornayvaz, Francois R., Estall, Jennifer L., Chatterjee Bhowmick, Diti, Shulman, Gerald I., Spiegelman, Bruce M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386123/
https://ncbi.nlm.nih.gov/pubmed/22645355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207287109
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