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The Triphosphate of β-D-4’-C-Ethynyl-2’,3’-Dideoxycytidine is the Preferred Enantiomer Substrate for HIV Reverse Transcriptase
The enantioselective synthesis of the β-D (1) enantiomer of 4’-C-ethynyl-2’,3’-dideoxycytidine confirms an earlier stereochemical assignment that was strictly based on the ability of HIV reverse transcriptase and its M184V mutant to discriminate between the D- and L-configuration of nucleoside 5’-tr...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1764207/ https://ncbi.nlm.nih.gov/pubmed/17046266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.09.061 |
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