Lack of Noggin Expression by Cancer Cells Is a Determinant of the Osteoblast Response in Bone Metastases

Prostate and mammary cancer bone metastases can be osteoblastic or osteolytic, but the mechanisms determining these features are unclear. Bone morphogenetic and Wnt proteins are osteoinductive molecules. Their activity is modulated by antagonists such as noggin and dickkopf-1. Differential expressio...

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Hauptverfasser: Schwaninger, Ruth, Rentsch, Cyrill A., Wetterwald, Antoinette, van der Horst, Geertje, van Bezooijen, Rutger L., van der Pluijm, Gabri, Löwik, Clemens W.G.M., Ackermann, Karin, Pyerin, Walter, Hamdy, Freddie C., Thalmann, George N., Cecchini, Marco G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2007
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Regular Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762703/
https://ncbi.nlm.nih.gov/pubmed/17200191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.051276
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