Lack of Noggin Expression by Cancer Cells Is a Determinant of the Osteoblast Response in Bone Metastases

Prostate and mammary cancer bone metastases can be osteoblastic or osteolytic, but the mechanisms determining these features are unclear. Bone morphogenetic and Wnt proteins are osteoinductive molecules. Their activity is modulated by antagonists such as noggin and dickkopf-1. Differential expressio...

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Hlavní autoři: Schwaninger, Ruth, Rentsch, Cyrill A., Wetterwald, Antoinette, van der Horst, Geertje, van Bezooijen, Rutger L., van der Pluijm, Gabri, Löwik, Clemens W.G.M., Ackermann, Karin, Pyerin, Walter, Hamdy, Freddie C., Thalmann, George N., Cecchini, Marco G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2007
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762703/
https://ncbi.nlm.nih.gov/pubmed/17200191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.051276
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