The Molecular Signature of the Stroma Response in Prostate Cancer-Induced Osteoblastic Bone Metastasis Highlights Expansion of Hematopoietic and Prostate Epithelial Stem Cell Niches

The reciprocal interaction between cancer cells and the tissue-specific stroma is critical for primary and metastatic tumor growth progression. Prostate cancer cells colonize preferentially bone (osteotropism), where they alter the physiological balance between osteoblast-mediated bone formation and...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Özdemir, Berna C., Hensel, Janine, Secondini, Chiara, Wetterwald, Antoinette, Schwaninger, Ruth, Fleischmann, Achim, Raffelsberger, Wolfgang, Poch, Olivier, Delorenzi, Mauro, Temanni, Ramzi, Mills, Ian G., van der Pluijm, Gabri, Thalmann, George N., Cecchini, Marco G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259356/
https://ncbi.nlm.nih.gov/pubmed/25485970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114530
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