Complement C1q Reduces Early Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

We explored the role of the classic complement pathway in atherogenesis by intercrossing C1q-deficient mice (C1qa(−/−)) with low-density lipoprotein receptor knockout mice (Ldlr(−/−)). Mice were fed a normal rodent diet until 22 weeks of age. Aortic root lesions were threefold larger in C1qa(−/−)/Ld...

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Detaylı Bibliyografya
Asıl Yazarlar: Bhatia, Vinay K., Yun, Sheng, Leung, Viola, Grimsditch, David C., Benson, G. Martin, Botto, Marina B., Boyle, Joseph J., Haskard, Dorian O.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2007
Konular:
Regular Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762701/
https://ncbi.nlm.nih.gov/pubmed/17200212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060406
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