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Immunoglobulin M is Required for Protection Against Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

BACKGROUND: IgM natural antibodies bind oxidatively modified low-density lipoprotein (LDL) and apoptotic cells and have been implicated as important for protection from atherosclerosis. We have directly investigated the requirement for IgM by studying the effects of IgM deficiency in LDL receptor-de...

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Détails bibliographiques
Auteurs principaux: Lewis, Myles J., Malik, Talat H., Ehrenstein, Michael R., Boyle, Joseph J., Botto, Marina, Haskard, Dorian O.
Format: Artigo
Langue:Inglês
Publié: 2009
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761224/
https://ncbi.nlm.nih.gov/pubmed/19620499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.868158
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