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Complement C1q Reduces Early Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice
We explored the role of the classic complement pathway in atherogenesis by intercrossing C1q-deficient mice (C1qa(−/−)) with low-density lipoprotein receptor knockout mice (Ldlr(−/−)). Mice were fed a normal rodent diet until 22 weeks of age. Aortic root lesions were threefold larger in C1qa(−/−)/Ld...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Investigative Pathology
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1762701/ https://ncbi.nlm.nih.gov/pubmed/17200212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060406 |
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