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The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control

Alteration of the FHIT (fragile histidine triad) gene occurs as an early and frequent event in lung carcinogenesis. FHIT gene transfer into lung cancer cell line H460 lacking Fhit protein expression resulted in reversion of tumorigenicity. To gain insight into the biological function of FHIT, we com...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Sard, Laura, Accornero, Paola, Tornielli, Silvana, Delia, Domenico, Bunone, Giuseppe, Campiglio, Manuela, Colombo, Mario P., Gramegna, Marcella, Croce, Carlo M., Pierotti, Marco A., Sozzi, Gabriella
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17543/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10411902/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.15.8489
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