The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control

Alteration of the FHIT (fragile histidine triad) gene occurs as an early and frequent event in lung carcinogenesis. FHIT gene transfer into lung cancer cell line H460 lacking Fhit protein expression resulted in reversion of tumorigenicity. To gain insight into the biological function of FHIT, we com...

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Main Authors: Sard, Laura, Accornero, Paola, Tornielli, Silvana, Delia, Domenico, Bunone, Giuseppe, Campiglio, Manuela, Colombo, Mario P., Gramegna, Marcella, Croce, Carlo M., Pierotti, Marco A., Sozzi, Gabriella
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 1999
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC17543/
https://ncbi.nlm.nih.gov/pubmed/10411902
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