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The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control

Alteration of the FHIT (fragile histidine triad) gene occurs as an early and frequent event in lung carcinogenesis. FHIT gene transfer into lung cancer cell line H460 lacking Fhit protein expression resulted in reversion of tumorigenicity. To gain insight into the biological function of FHIT, we com...

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Gespeichert in:
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Sard, Laura, Accornero, Paola, Tornielli, Silvana, Delia, Domenico, Bunone, Giuseppe, Campiglio, Manuela, Colombo, Mario P., Gramegna, Marcella, Croce, Carlo M., Pierotti, Marco A., Sozzi, Gabriella
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1999
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17543/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10411902/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.15.8489
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