Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1

We have determined the crystal structure at 2.3-Å resolution of an amino-terminal segment of human insulin receptor substrate 1 that encompasses its pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains. Both domains adopt the canonical seven-stranded β-sandwich PH domain fold. The doma...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Dhe-Paganon, Sirano, Ottinger, Elizabeth A., Nolte, Robert T., Eck, Michael J., Shoelson, Steven E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17524/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10411883/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.15.8378
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