Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1

We have determined the crystal structure at 2.3-Å resolution of an amino-terminal segment of human insulin receptor substrate 1 that encompasses its pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains. Both domains adopt the canonical seven-stranded β-sandwich PH domain fold. The doma...

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Detalhes bibliográficos
Main Authors: Dhe-Paganon, Sirano, Ottinger, Elizabeth A., Nolte, Robert T., Eck, Michael J., Shoelson, Steven E.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC17524/
https://ncbi.nlm.nih.gov/pubmed/10411883
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