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Location of Binding Sites in Small Molecule Rescue of Human Carbonic Anhydrase II
Small molecule rescue of mutant forms of human carbonic anhydrase II (HCA II) occurs by participation of exogenous donors/acceptors in the proton transfer pathway between the zinc-bound water and solution. To examine more thoroughly the energetics of this activation, we have constructed a mutant, H6...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1751391/ https://ncbi.nlm.nih.gov/pubmed/17071654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.093203 |
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