Helicobacter pylori cytotoxin: importance of native conformation for induction of neutralizing antibodies.

We have attempted to express the Helicobacter pylori vacuolating cytotoxin in Escherichia coli. Although the 95-kDa VacA polypeptide was expressed abundantly, it completely lacked any biological activity. In addition, this material failed to induce neutralizing antibodies after immunization of rabbi...

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Bibliografske podrobnosti

izdano v:	Infect Immun
Principais autores:	Manetti, R, Massari, P, Burroni, D, de Bernard, M, Marchini, A, Olivieri, R, Papini, E, Montecucco, C, Rappuoli, R, Telford, J L
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1995
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC173637/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7591088/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.63.11.4476-4480.1995
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