Helicobacter pylori cytotoxin: importance of native conformation for induction of neutralizing antibodies.

We have attempted to express the Helicobacter pylori vacuolating cytotoxin in Escherichia coli. Although the 95-kDa VacA polypeptide was expressed abundantly, it completely lacked any biological activity. In addition, this material failed to induce neutralizing antibodies after immunization of rabbi...

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Hauptverfasser: Manetti, R, Massari, P, Burroni, D, de Bernard, M, Marchini, A, Olivieri, R, Papini, E, Montecucco, C, Rappuoli, R, Telford, J L
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC173637/
https://ncbi.nlm.nih.gov/pubmed/7591088
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