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Intracellular inclusions, pathological markers in diseases caused by expanded polyglutamine tracts?
The largest group of currently known trinucleotide repeat diseases is caused by (CAG)(n) repeat expansions. These (CAG)(n) repeats are translated into polyglutamine tracts from both mutant and wild type alleles. Genetic and transgenic mouse data suggest that the expanded polyglutamines cause disease...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMJ Group
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1734357/ https://ncbi.nlm.nih.gov/pubmed/10227391 |
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