Cytoplasmic Inclusions of Htt Exon1 Containing an Expanded Polyglutamine Tract Suppress Execution of Apoptosis in Sympathetic Neurons

Proteins containing extended polyglutamine repeats cause at least nine neurodegenerative disorders, but the mechanisms of disease-related neuronal death remain uncertain. We show that sympathetic neurons containing cytoplasmic inclusions formed by 97 glutamines expressed within human huntingtin exon...

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Publicat a:J Neurosci
Autors principals: King, Matthew A., Goemans, Christoph G., Hafiz, Farida, Prehn, Jochen H. M., Wyttenbach, Andreas, Tolkovsky, Aviva M.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671245/
https://ncbi.nlm.nih.gov/pubmed/19118173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4751-08.2008
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