Cytoplasmic Inclusions of Htt Exon1 Containing an Expanded Polyglutamine Tract Suppress Execution of Apoptosis in Sympathetic Neurons

Proteins containing extended polyglutamine repeats cause at least nine neurodegenerative disorders, but the mechanisms of disease-related neuronal death remain uncertain. We show that sympathetic neurons containing cytoplasmic inclusions formed by 97 glutamines expressed within human huntingtin exon...

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Detalhes bibliográficos
Publicado no:J Neurosci
Principais autores: King, Matthew A., Goemans, Christoph G., Hafiz, Farida, Prehn, Jochen H. M., Wyttenbach, Andreas, Tolkovsky, Aviva M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671245/
https://ncbi.nlm.nih.gov/pubmed/19118173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4751-08.2008
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