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The expanding role for chromatin and transcription in polyglutamine disease

Nine genetic diseases arise from expansion of CAG repeats in seemingly unrelated genes. They are referred to as polyglutamine (polyQ) diseases due to the presence of elongated glutamine tracts in the corresponding proteins. The pathologic consequences of polyQ expansion include progressive spinal, c...

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Bibliografiske detaljer
Udgivet i:Curr Opin Genet Dev
Main Authors: Mohan, Ryan D., Abmayr, Susan M., Workman, Jerry L.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253674/
https://ncbi.nlm.nih.gov/pubmed/25108806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2014.06.008
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