Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase

Poly(ADP-ribose) polymerase (PARP) is implicated in the maintenance of genomic integrity, given that inhibition or depletion of this enzyme increases genomic instability in cells exposed to genotoxic agents. We previously showed that immortalized fibroblasts derived from PARP(−/−) mice exhibit an un...

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Auteurs principaux: Simbulan-Rosenthal, Cynthia M., Ly, Danith H., Rosenthal, Dean S., Konopka, Genevieve, Luo, RuiBai, Wang, Zhao-Qi, Schultz, Peter G., Smulson, Mark E.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 2000
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC17190/
https://ncbi.nlm.nih.gov/pubmed/11016956
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