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Chromosomal aberrations in PARP(−/−) mice: Genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA

Depletion of poly(ADP-ribose) polymerase (PARP) increases the frequency of recombination, gene amplification, sister chromatid exchanges, and micronuclei formation in cells exposed to genotoxic agents, implicating PARP in the maintenance of genomic stability. Flow cytometric analysis now has reveale...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Simbulan-Rosenthal, Cynthia M., Haddad, Bassem R., Rosenthal, Dean S., Weaver, Zoë, Coleman, Allen, Luo, RuiBai, Young, Hannah M., Wang, Zhao-Qi, Ried, Thomas, Smulson, Mark E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23923/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10557296/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.23.13191
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