Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

Activation of peroxisome proliferator-activated receptor γ (PPARγ) by thiazolidinediones (TZDs) improves insulin resistance by increasing insulin-stimulated glucose disposal in skeletal muscle. It remains debatable whether the effect of TZDs on muscle is direct or indirect via adipose tissue. We the...

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Main Authors: Norris, Andrew W., Chen, Lihong, Fisher, Simon J., Szanto, Ildiko, Ristow, Michael, Jozsi, Alison C., Hirshman, Michael F., Rosen, Evan D., Goodyear, Laurie J., Gonzalez, Frank J., Spiegelman, Bruce M., Kahn, C. Ronald
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC171387/
https://ncbi.nlm.nih.gov/pubmed/12925701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317305
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