PPARγ deacetylation dissociates thiazolidinedione’s metabolic benefits from its adverse effects

Thiazolidinediones (TZDs) are PPARγ agonists with potent insulin-sensitizing effects. However, their use has been curtailed by substantial adverse effects on weight, bone, heart, and hemodynamic balance. TZDs induce the deacetylation of PPARγ on K268 and K293 to cause the browning of white adipocyte...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Kraakman, Michael J., Liu, Qiongming, Postigo-Fernandez, Jorge, Ji, Ruiping, Kon, Ning, Larrea, Delfina, Namwanje, Maria, Fan, Lihong, Chan, Michelle, Area-Gomez, Estela, Fu, Wenxian, Creusot, Remi J., Qiang, Li
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983311/
https://ncbi.nlm.nih.gov/pubmed/29589839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98709
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