Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

Activation of peroxisome proliferator-activated receptor γ (PPARγ) by thiazolidinediones (TZDs) improves insulin resistance by increasing insulin-stimulated glucose disposal in skeletal muscle. It remains debatable whether the effect of TZDs on muscle is direct or indirect via adipose tissue. We the...

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Bibliografiske detaljer
Main Authors: Norris, Andrew W., Chen, Lihong, Fisher, Simon J., Szanto, Ildiko, Ristow, Michael, Jozsi, Alison C., Hirshman, Michael F., Rosen, Evan D., Goodyear, Laurie J., Gonzalez, Frank J., Spiegelman, Bruce M., Kahn, C. Ronald
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC171387/
https://ncbi.nlm.nih.gov/pubmed/12925701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317305
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