Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

Activation of peroxisome proliferator-activated receptor γ (PPARγ) by thiazolidinediones (TZDs) improves insulin resistance by increasing insulin-stimulated glucose disposal in skeletal muscle. It remains debatable whether the effect of TZDs on muscle is direct or indirect via adipose tissue. We the...

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Detalhes bibliográficos
Main Authors: Norris, Andrew W., Chen, Lihong, Fisher, Simon J., Szanto, Ildiko, Ristow, Michael, Jozsi, Alison C., Hirshman, Michael F., Rosen, Evan D., Goodyear, Laurie J., Gonzalez, Frank J., Spiegelman, Bruce M., Kahn, C. Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC171387/
https://ncbi.nlm.nih.gov/pubmed/12925701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317305
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