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Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes

In the Drosophila RNA interference (RNAi) pathway, small interfering RNAs (siRNAs) direct Argonaute2 (Ago2), an endonuclease, within the RNA-induced silencing complex (RISC) to cleave complementary mRNA targets. In vitro studies have shown that, for each siRNA duplex, RISC retains only one strand, t...

詳細記述

保存先:
書誌詳細
主要な著者: Kim, Kevin, Lee, Young Sik, Carthew, Richard W.
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1705758/
https://ncbi.nlm.nih.gov/pubmed/17123955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.283207
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