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Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes
In the Drosophila RNA interference (RNAi) pathway, small interfering RNAs (siRNAs) direct Argonaute2 (Ago2), an endonuclease, within the RNA-induced silencing complex (RISC) to cleave complementary mRNA targets. In vitro studies have shown that, for each siRNA duplex, RISC retains only one strand, t...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1705758/ https://ncbi.nlm.nih.gov/pubmed/17123955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.283207 |
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