Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme

Short interfering RNA (siRNA) duplexes are currently being evaluated as antisense agents for gene silencing. Chemical modification of siRNAs is widely expected to be required for therapeutic applications in order to improve delivery, biostability and pharmacokinetic properties. Beyond potential impr...

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Detalhes bibliográficos
Main Authors: Li, Feng, Pallan, Pradeep S., Maier, Martin A., Rajeev, Kallanthottathil G., Mathieu, Steven L., Kreutz, Christoph, Fan, Yupeng, Sanghvi, Jayodita, Micura, Ronald, Rozners, Eriks, Manoharan, Muthiah, Egli, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2095806/
https://ncbi.nlm.nih.gov/pubmed/17881374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm664
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