Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme

Short interfering RNA (siRNA) duplexes are currently being evaluated as antisense agents for gene silencing. Chemical modification of siRNAs is widely expected to be required for therapeutic applications in order to improve delivery, biostability and pharmacokinetic properties. Beyond potential impr...

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Hlavní autoři: Li, Feng, Pallan, Pradeep S., Maier, Martin A., Rajeev, Kallanthottathil G., Mathieu, Steven L., Kreutz, Christoph, Fan, Yupeng, Sanghvi, Jayodita, Micura, Ronald, Rozners, Eriks, Manoharan, Muthiah, Egli, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2007
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2095806/
https://ncbi.nlm.nih.gov/pubmed/17881374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm664
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