Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme

Short interfering RNA (siRNA) duplexes are currently being evaluated as antisense agents for gene silencing. Chemical modification of siRNAs is widely expected to be required for therapeutic applications in order to improve delivery, biostability and pharmacokinetic properties. Beyond potential impr...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Li, Feng, Pallan, Pradeep S., Maier, Martin A., Rajeev, Kallanthottathil G., Mathieu, Steven L., Kreutz, Christoph, Fan, Yupeng, Sanghvi, Jayodita, Micura, Ronald, Rozners, Eriks, Manoharan, Muthiah, Egli, Martin
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2007
Sujets:
Structural Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2095806/
https://ncbi.nlm.nih.gov/pubmed/17881374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm664
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires