Načítá se...

Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme

Short interfering RNA (siRNA) duplexes are currently being evaluated as antisense agents for gene silencing. Chemical modification of siRNAs is widely expected to be required for therapeutic applications in order to improve delivery, biostability and pharmacokinetic properties. Beyond potential impr...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Li, Feng, Pallan, Pradeep S., Maier, Martin A., Rajeev, Kallanthottathil G., Mathieu, Steven L., Kreutz, Christoph, Fan, Yupeng, Sanghvi, Jayodita, Micura, Ronald, Rozners, Eriks, Manoharan, Muthiah, Egli, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2095806/
https://ncbi.nlm.nih.gov/pubmed/17881374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm664
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!