Alternative RISC assembly: Binding and repression of microRNA–mRNA duplexes by human Ago proteins

MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate protein output from the majority of human mRNAs. In contrast to the consensus view that all miRNAs are associated with Argonaute (Ago) proteins, we determine that miRNAs are expressed in a 13-fold excess relative to Ago...

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Autori principali: Janas, Maja M., Wang, Bingbing, Harris, Abigail S., Aguiar, Mike, Shaffer, Jonathan M., Subrahmanyam, Yerramilli V.B.K., Behlke, Mark A., Wucherpfennig, Kai W., Gygi, Steven P., Gagnon, Etienne, Novina, Carl D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479394/
https://ncbi.nlm.nih.gov/pubmed/23019594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.035675.112
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