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Alternative RISC assembly: Binding and repression of microRNA–mRNA duplexes by human Ago proteins

MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate protein output from the majority of human mRNAs. In contrast to the consensus view that all miRNAs are associated with Argonaute (Ago) proteins, we determine that miRNAs are expressed in a 13-fold excess relative to Ago...

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Detalles Bibliográficos
Main Authors: Janas, Maja M., Wang, Bingbing, Harris, Abigail S., Aguiar, Mike, Shaffer, Jonathan M., Subrahmanyam, Yerramilli V.B.K., Behlke, Mark A., Wucherpfennig, Kai W., Gygi, Steven P., Gagnon, Etienne, Novina, Carl D.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479394/
https://ncbi.nlm.nih.gov/pubmed/23019594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.035675.112
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