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Asymmetry of intronic pre-miRNA structures in functional RISC assembly

The two oligonucleotide strands of a siRNA duplex are functionally asymmetric in assembling the RNAi effector, RNA-induced gene silencing complex (RISC). Based on this asymmetric RISC assembly model in vitro, formation of a microRNA (miRNA) and complementary miRNA (miRNA*) duplex was proposed to be...

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Hlavní autoři: Lin, Shi-Lung, Chang, Donald, Ying, Shao-Yao
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1788082/
https://ncbi.nlm.nih.gov/pubmed/16005165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2005.04.036
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