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Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-αBcrystallin) complex
Growth factor-dependent accumulation of the cyclin D1 proto-oncogene is balanced by its rapid phosphorylation-dependent proteolysis. Degradation is triggered by threonine 286 phosphorylation, which promotes its ubiquitination by an unknown E3 ligase. We demonstrate that Thr286 phosphorylated cyclin...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1702390/ https://ncbi.nlm.nih.gov/pubmed/17081987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.09.007 |
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