Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-αBcrystallin) complex

Growth factor-dependent accumulation of the cyclin D1 proto-oncogene is balanced by its rapid phosphorylation-dependent proteolysis. Degradation is triggered by threonine 286 phosphorylation, which promotes its ubiquitination by an unknown E3 ligase. We demonstrate that Thr286 phosphorylated cyclin...

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Bibliografiske detaljer
Main Authors: Lin, Douglas I., Barbash, Olena, Kumar, K.G. Suresh, Weber, Jason D., Harper, J. Wade, Klein-Szanto, Andres J. P., Rustgi, Anil, Fuchs, Serge Y., Diehl, J. Alan
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1702390/
https://ncbi.nlm.nih.gov/pubmed/17081987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.09.007
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