Structural Basis of Selective Ubiquitination of TRF1 by SCF(Fbx4)

TRF1 is a critical regulator of telomere length. As such, TRF1 levels are regulated by ubiquitin-dependent proteolysis via an SCF E3 ligase where Fbx4 contributes substrate specification. Here we report the crystal structure of the Fbx4-TRF1 complex at 2.4 Å resolution. Fbx4 contains a unusual subst...

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Foilsithe in:Dev Cell
Main Authors: Zeng, Zhixiong, Wang, Wei, Yang, Yuting, Chen, Yong, Yang, Xiaomei, Diehl, J. Alan, Liu, Xuedong, Lei, Ming
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097615/
https://ncbi.nlm.nih.gov/pubmed/20159592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.01.007
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