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Structural Basis of Selective Ubiquitination of TRF1 by SCF(Fbx4)
TRF1 is a critical regulator of telomere length. As such, TRF1 levels are regulated by ubiquitin-dependent proteolysis via an SCF E3 ligase where Fbx4 contributes substrate specification. Here we report the crystal structure of the Fbx4-TRF1 complex at 2.4 Å resolution. Fbx4 contains a unusual subst...
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| Pubblicato in: | Dev Cell |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6097615/ https://ncbi.nlm.nih.gov/pubmed/20159592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.01.007 |
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