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Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3ε

Fbx4 is an F-box constituent of SCF ubiquitin ligases that directs ubiquitylation of cyclin D1. Ubiquitylation of cyclin D1 requires phosphorylation of both cyclin D1 and Fbx4 by GSK3β. GSK3β-mediated phosphorylation of Fbx4 Ser12 during the G1/S transition regulates Fbx4 dimerization, which in turn...

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Hlavní autoři: Barbash, Olena, Lee, Eric K., Diehl, J Alan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084329/
https://ncbi.nlm.nih.gov/pubmed/21242966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.584
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